GKD Anest Yoð Bak Dern Derg. 2021; 27(1): 30-37 | DOI: 10.5222/GKDAD.2021.63634

The Effect of Two Different Types of Anesthesia on Postoperative Liver Functions in Patients with Coronary Bypass with Metabolic Syndrome

Hülya Yiðit Özay¹, Aslý Demir¹, Melike Kaya Bahçecitapar^2
1Ankara City Hospital, Department Of Anesthesiology And Reanimation, Ankara
²Hacettepe University, Department Of Statistics, Ankara

Objective: One of the factors affecting liver functions in open coronary surgery (CABG) of patients with metabolic syndrome (MS) may be the anesthetic drugs used. For this purpose, we investigated the effects of midazolam-based total intravenous anesthesia (TIVA) and sevoflurane-based inhalation anesthesia on liver functions and postoperative complications in patients with MS who wiould undergo open coronary bypass surgery.
Method: A total f 76 patients were included in our study. A statistically significant difference was not found between the TIVA (n=38) and SEVO (n=38) groups in terms of gender, age, body mass index (BMI), Euroscore values, presence of preoperative comorbidity, blood product transfusion, postoperative complications, and 30-day mortality rates. (p>0.05). Preoperative and postoperative laboratory parameters, ALT, AST, LDH, and glucose values were comparable between both groups.
Results: 76 patients were included in our study. There was a statistically significant difference between the TIVA (n=38) and SEVO (n=38) groups in terms of gender, age, body mass index (BMI), euroscore values, presence of preoperative comorbidity, blood product transfusion, postoperative complications, and 30-day mortality rates. There was no difference (p>0.05). When compared according to preoperative and postoperative laboratory parameters, ALT, AST, LDH, and glucose values were found similar in both groups.
Conclusion: In our study, we found that TIVA and SEVO groups are not superior to each other in coronary bypass patients with metabolic syndrome. Studies investigating detailed parameters with more patients will be guiding for this issue.

Keywords: Metabolic syndrome, coronary bypass surgery, sevoflurane, midazolam, obesity

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Metabolik Sendromlu Koroner Baypas Hastalarýnda Uygulanan Ýki Farklý Anestezi Tipinin Postoperatif Karaciðer Fonksiyonlarý Üzerine Etkisi

Hülya Yiðit Özay¹, Aslý Demir¹, Melike Kaya Bahçecitapar^2
1Ankara Þehir Hastanesi Anesteziyoloji Ve Reanimasyon Kliniði, Ankara
²Hacettepe Üniversitesi Ýstatistik Anabilimdalý, Ankara

Amaç: Metabolik sendromlu (MS) hastalarýn koroner baypas cerrahisinde (KABG) karaciðer fonksiyonlarýný etkileyen faktörlerden biri kullanýlan anestezi ilaçlarý olabilir. Bu amaçla KABG geçirecek MS’lu hastalarda, midazolam bazlý total intravenöz anestezi(TÝVA) ve sevofluran bazlý inhalasyon anestezi uygulamasýnýn, karaciðer fonksiyonlarý ve postoperatif komplikasyonlar üzerine etkilerini araþtýrdýk.
Yöntem: Çalýþmamýza 76 hasta dâhil edildi. TÝVA (n=38) ve SEVO (n=38) gruplarý arasýnda cinsiyet, yaþ, vücut kitle indeksi (VKÝ), euroscore deðerleri, ameliyat öncesi komorbidite varlýðý, kan ürünü transfüzyonu, postoperatif komplikasyon ve 30 günlük mortalite oranlarý açýsýndan istatistiksel olarak anlamlý bir fark yoktu (p>0.05). Preoperatif ve postoperatif laboratuvar parametrelerine göre karþýlaþtýrýldýðýnda her 2 grupta da ALT, AST, LDH ve glukoz deðerleri benzer bulundu.
Bulgular: Çalýþmamýzda, metabolik sendromlu koroner baypas hastalarýnda midazolam bazlý TÝVA ve sevofluran bazlý inhalasyon anestezi uygulamalarýnýn birbirine üstünlüðü olmadýðýný saptadýk. Daha fazla sayýda hasta ile detaylý parametrelerin araþtýrýldýðý çalýþmalar bu konu için yol gösterici olacaktýr.
Sonuç: Çalýþmamýzda, metabolik sendromlu koroner baypas hastalarýnda midazolam bazlý TÝVA ve sevofluran bazlý inhalasyon anestezi uygulamalarýnýn birbirine üstünlüðü olmadýðýný saptadýk. Daha fazla sayýda hasta ile detaylý parametrelerin araþtýrýldýðý çalýþmalar bu konu için yol gösterici olacaktýr.

Anahtar Kelimeler: Metabolik sendrom, koroner baypas cerrahisi, sevofluran, midazolam, obezite

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