Relationship Between Diameter of the Cannula, Vascular Access Site Used and Gender and the Pain Perception of Intravenous Injection of Propofol and Rocuronium

INTRODUCTION: With an incidence of 24-80%,injection pain of propofol is it’s most well known and most frequent side effect. Recuronium, a steroidal nondepolarizing muscle relaxant, is also among agents which can cause injection pain. The goal of our study was to investigate the relevance of cannula diameter, location of vascular access and gender in pain perception of intravenous injection of propofol and rocuronium.
METHODS: 637 patients in ASA I-II groups between the ages of 16-80 were included in this study, whose operations were planned with general anesthesia in XXX Hospital between June 1st 2012 and December 31st 2012. Cases were divided into four groups according to cannulation location and cannula diameter as: Group 1 (hand 20 gauge), group 2 (antecubital zone 20 gauge), group 3 (hand 22 gauge) and group 4 (antecubital zone 22 gauge).
RESULTS: There was no significant difference between patients’ demographic factors and initial hemodynamic parameters. During propofol injection; while 387 out of 637 patients did not show pain reaction, 250 of them reacted at various degrees. During rocuronium injection of the same patients, while 335 of them did not describe any pain, 302 of them reacted variously. In group 3, 76.7% of men and 47.4% of women did not describe any pain with propofol injection. In the same group, 53.3% of men and 47.4% of women did not describe any pain with rocuronium injection.
DISCUSSION AND CONCLUSION: We observed that compared to men, women included in our study showed more pain reaction to both drugs’ hand injections with small diameter branules.

Propofol ve Roküronyum Ýntravenöz Enjeksiyon Aðrýsýnýn Algýlanmasýnda, Kullanýlan Damar Yolu Yeri, Kanül Çapý ve Cinsiyet Ýliþkisi

GÝRÝÞ ve AMAÇ: Propofolün enjeksiyon aðrýsý en iyi bilinen, en sýk karþýlaþýlan yan etkisidir ve
insidansý % 24-80’dir. Steroid yapýlý, nondepolarizan bir kas gevþetici olan roküronyum da
enjeksiyon aðrýsýna sebep olabilen ajanlardandýr. Çalýþmamýzda propofol ve roküronyum
enjeksiyon aðrýsýnýn algýlanmasýnda, kullanýlan damar yolunun yeri, kullanýlan intraketin çapý ve cinsiyet ile iliþkisinin karþýlaþtýrýlmasýný amaçladýk.

YÖNTEM ve GEREÇLER: Bu çalýþmaya, 1 Haziran 2012 ve 31 Aralýk 2012 tarihleri arasýnda
XXX Hastanesi ameliyathanesinde genel anestezi ile operasyonu planlanan 16-80
yaþ arasýnda ASA I-II grubundan 637 hasta dahil edildi. Olgular intravenöz (iv) kanülasyon yeri ve kullanýlan kanülün çapýna göre dört gruba ayrýldýlar. Grup 1 (el üstü 20 gauge), Grup 2 (antekubital bölge 20 gauge), Grup 3 (el üstü 22 gauge) ve Grup 4 (antekubital 22 gauge) olarak belirlendi.

BULGULAR: Hastalarýn demografik bulgularý ve ilk hemodinamik parametreleri arasýnda istatistiksel olarak anlamlý farklýlýk bulunmadý. Propofol enjeksiyonu esnasýnda; 637 hastanýn 387 tanesi aðrý tepkisi göstermezken, 250 tanesi çeþitli derecelerde aðrý tepkisi verdiler. Ayný hastalarýn 335 tanesi roküronyum enjeksiyonu esnasýnda aðrý tepkisi tariflemezken, 302 tanesi çeþitli derecelerde aðrý tepkisi gösterdiler. Grup 3’ de propofol enjeksiyonunda erkeklerin %76.7’ si, kadýnlarýn %47.4’ ü aðrý tepkisi göstermediler. Ayný gruptaki erkek hastalarýn %53.3’ü, kadýnlarýn %47.4’ ü roküronyum enjeksiyonunda aðrý tepkisi göstermediler.
TARTIÞMA ve SONUÇ: Çalýþmamýza katýlan kadýn hastalarýn erkek hastalara göre el üstü ve küçük çaplý intraketlerle açýlan damar yollarýnda her iki ilacýn enjeksiyonuna daha fazla aðrý tepkisi verdiðini tespit ettik.